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skp1

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Official Full Name
S-phase kinase-associated protein 1
Background
This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins. This protein binds directly to the F-box motif found in F-box proteins. SCF complexes are involved in the regulated ubiquitination of specific protein substrates, which targets them for degradation by the proteosome. Specific F-box proteins recognize different target protein(s), and many specific SCF substrates have been identified including regulators of cell cycle progression and development. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7.
Synonyms
SKP1; S-phase kinase-associated protein 1; OCP2; p19A; EMC19; SKP1A; OCP-II; TCEB1L; MGC34403; S-phase kinase-associated; protein 1; SIII; OCP-2; p19skp1; OTTHUMP00000159379; OTTHUMP00000159380; OTTHUMP00000228275; OTTHUMP00000228276; OTTHUMP00000228278; OTTHUMP00000228279; OTTHUMP00000228281; organ of Corti protein 2; organ of Corti protein II; cyclin A/CDK2-associated p19; transcription elongation factor B; cyclin A/CDK2-associated protein p19; cyclin-A/CDK2-associated protein p19; RNA polymerase II elongation factor-like protein OCP2; S phase kinase associated protein 1A (p19A) , SKP1A; OCP II; EMC19, MGC34403, OCP-II, OCP2, SKP1A, TCEB1L, p19A, SKP1; S-phase kinase-associated protein 1A; zgc:73186