SIM1 and SIM2 genes are Drosophila single-minded (sim) gene homologs. The Drosophila sim gene encodes a transcription;factor that is a master regulator of fruit fly neurogenesis. SIM2 maps within the so-called Down syndrome chromosomal;region. Based on the mapping position, its potential function as transcriptional repressor and similarity to;Drosophila sim, it is proposed that SIM2 may contribute to some specific Down syndrome phenotypes.
SIM2; single-minded homolog 2 (Drosophila); SIM, single minded (Drosophila) homolog 2; single-minded homolog 2; bHLHe15; MGC119447; transcription factor SIM2; Class E basic helix loop helix protein 15; Class E basic helix-loop-helix protein 15; SIM 2; SIM; SIM2_HUMAN; Single minded homolog 2 (Drosophila); Single minded homolog 2; OTTHUMP00000109043; OTTHUMP00000109044; single-minded homolog 2, short isoform; HMC13F06; HMC29C01; SIM, bHLHe15, HMC13F06, HMC29C01; single-minded family bHLH transcription factor 2