Tel: 1-631-626-9181 (USA)   44-207-097-1828 (Europe)

CBpromise   

Our promise to you:
Guaranteed product quality, expert customer support.

24x7 CUSTOMER SERVICE
CONTACT US TO ORDER

siglec8

Bookmark and Share
Official Full Name
sialic acid binding Ig-like lectin 8
Background
Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1;transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of;the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic;tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif;homologous to one identified in signaling lymphocyte activation molecule (SLAM; MIM 603492) that mediates an;association with SLAM-associated protein (SAP; MIM 300490) (summarized by Foussias et al., 2000 (PubMed;11095983)).
Synonyms
SIGLEC8; sialic acid binding Ig-like lectin 8; sialic acid-binding Ig-like lectin 8; MGC59785; SAF2; SIGLEC 8; SIGLEC8L; SAF-2; CDw329; sialoadhesin family member 2; SIGLEC-8