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siah1

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Official Full Name
siah E3 ubiquitin protein ligase 1
Background
This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinsons disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
Synonyms
SIAH1; seven in absentia homolog 1 (Drosophila); E3 ubiquitin-protein ligase SIAH1; hSIAH1; HUMSIAH; Seven in absentia homolog 1; SIAH 1; Siah 1a; Ubiquitin ligase SIAH1; siah-1a; OTTHUMP00000164188; OTTHUMP00000164189; SIAH1A; siah E3 ubiquitin protein ligase 1; FLJ08065; zgc:56026; id:ibd2635; siah-1; seven in absentia 1A