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sf3b3

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Official Full Name
splicing factor 3b, subunit 3, 130kDa
Background
This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the introns branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (histone acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair.
Synonyms
SF3B3; splicing factor 3b, subunit 3, 130kDa; splicing factor 3b, subunit 3, 130kD; splicing factor 3B subunit 3; KIAA0017; RSE1; SAP130; SF3b130; SAP 130; OTTHUMP00000174907; spliceosome-associated protein 130; pre-mRNA-splicing factor SF3b 130 kDa subunit; pre-mRNA splicing factor SF3b, 130 kDa subunit; STAF130; splicing factor 3b, subunit 3; zgc:55440; wu:fb81f05; ik:tdsubc_2b2; xx:tdsubc_2b2