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sf3b1

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Official Full Name
splicing factor 3b, subunit 1, 155kDa
Background
This gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the introns branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Synonyms
SF3B1; splicing factor 3b, subunit 1, 155kDa; MDS; PRP10; Hsh155; PRPF10; SAP155; SF3b155; splicing factor 3B subunit 1; SAP 155; pre-mRNA processing 10; spliceosome-associated protein 155; pre-mRNA splicing factor SF3b, 155 kDa subunit