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setdb2

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Official Full Name
SET domain, bifurcated 2
Background
Proteins that contain a SET domain, such as SETDB2, modulate gene expression epigenetically through histone H3 (see MIM 601128) methylation. SETDB2 is likely a histone H3 methyltransferase, as it contains both the active site and flanking cysteine residues required for catalytic activity (Zhang et al., 2003 [PubMed 12754510]).[supplied by OMIM, Mar 2008]
Synonyms
SETDB2; SET domain, bifurcated 2; CLLD8; CLLL8; KMT1F; C13orf4; histone-lysine N-methyltransferase SETDB2; lysine N-methyltransferase 1F; chronic lymphocytic leukemia deletion region 8; chronic lymphocytic leukemia deletion region gene 8 protein; C13orf4, chromosome 13 open reading frame 4; DKFZp586I0123; DKFZp761J1217; CLLD8, CLLL8, KMT1F, C13orf4; zgc:77298; wu:fk80d09

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