This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
SESN1; sestrin 1; sestrin-1; PA26; SEST1; AU044290; MGC142129; RP11-787I22.1; 1110002G11Rik; MGC118148; MGC138241; OTTMUSP00000022799; p53 regulated PA26 nuclear protein; p53 regulated protein PA26; p53-regulated protein PA26; SESN1_HUMAN; OTTHUMP00000016951; OTTHUMP00000016952; OTTHUMP00000016953; p53 activated gene 26; zgc:91970