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serpinc1

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Official Full Name
serpin peptidase inhibitor, clade C (antithrombin), member 1
Background
The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency.
Synonyms
SERPINC1; serpin peptidase inhibitor, clade C (antithrombin), member 1; AT3; ATIII; MGC22579; antithrombin (aa 375-432); antithrombin III; coding sequence signal peptide antithrombin part 1; signal peptide antithrombin part 1; serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1; Antithrombin-III; Serpin C1; PRO0309; OTTHUMP00000035393; serine-cysteine proteinase inhibitor clade C member 1; AT3, serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1; antithrombin (aa 375 432); AT3D; THPH7; AT3, ATIII, MGC22579; zgc:92299; wu:fb18f10

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