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serpinb8

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Official Full Name
serpin peptidase inhibitor, clade B (ovalbumin), member 8
Background
The superfamily of high molecular weight serine proteinase inhibitors (serpins) regulate a diverse set of intracellular;and extracellular processes such as complement activation, fibrinolysis, coagulation, cellular differentiation, tumor;suppression, apoptosis, and cell migration. Serpins are characterized by well-conserved a tertiary structure that;consists of 3 beta sheets and 8 or 9 alpha helices (Huber and Carrell, 1989 (PubMed 2690952)). A critical portion of;the molecule, the reactive center loop connects beta sheets A and C. Protease inhibitor-8 (PI8; SERPINB8) is a member;of the ov-serpin subfamily, which, relative to the archetypal serpin PI1 (MIM 107400), is characterized by a high;degree of homology to chicken ovalbumin, lack of N- and C-terminal extensions, absence of a signal peptide, and a;serine rather than an asparagine residue at the penultimate position (summary by Bartuski et al., 1997 (PubMed;9268635)).
Synonyms
SERPINB8; serpin peptidase inhibitor, clade B (ovalbumin), member 8; PI8, serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 8; serpin B8; CAP2; cytoplasmic antiproteinase 2; CAP 2; CAP-2; OTTHUMP00000067000; OTTHUMP00000067001; Peptidase inhibitor 8; PI-8; PI8; Protease inhibitor 8 (ovalbumin type); Serine (or cysteine) proteinase inhibitor clade B (ovalbumin) member 8; Serpin peptidase inhibitor clade B (ovalbumin) member 8; SPB8_HUMAN; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 8; NK10; Spi8; ovalbumin