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scn11a

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Official Full Name
sodium channel, voltage-gated, type XI, alpha subunit
Background
Voltage-gated sodium channels are membrane protein complexes that play a fundamental role in the rising phase of the;action potential in most excitable cells. Alpha subunits, such as SCN11A, mediate voltage-dependent gating and;conductance, while auxiliary beta subunits regulate the kinetic properties of the channel and facilitate membrane;localization of the complex. Aberrant expression patterns or mutations of alpha subunits underlie a number of;disorders. Each alpha subunit consists of 4 domains connected by 3 intracellular loops; each domain consists of 6;transmembrane segments and intra- and extracellular linkers.
Synonyms
SCN11A; sodium channel, voltage-gated, type XI, alpha subunit; SCN12A, sodium channel, voltage gated, type XI, alpha polypeptide , sodium channel, voltage gated, type XII, alpha; sodium channel protein type 11 subunit alpha; NaN; Nav1.9; SNS 2; hNaN; Peripheral nerve sodium channel 5; PN 5; PN5; SCN 11A; SCN 12A; SCN12A; Sensory neuron sodium channel 2; SNS2; Sodium channel protein type XI subunit alpha; Sodium channel voltage gated type XI alpha; Sodium channel voltage gated type XI alpha polypeptide; Sodium channel voltage gated type XI alpha subunit; Sodium channel voltage gated type XII alpha polypeptide; Voltage gated sodium channel Nav1.9; Voltage gated sodium channel subunit alpha Nav1.9; OTTHUMP00000045937; OTTHUMP00000209286; OTTHUMP00000209287; voltage-gated sodium channel Nav1.9; sodium channel protein type XI subunit alp; SNS-2