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sars2

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Official Full Name
seryl-tRNA synthetase 2, mitochondrial
Background
This gene encodes the mitochondrial seryl-tRNA synthethase precursor, a member of the class II tRNA synthetase family. The mature enzyme catalyzes the ligation of Serine to tRNA(Ser) and participates in the biosynthesis of selenocysteinyl-tRNA(sec) in mitochondria. The enzyme contains an N-terminal tRNA binding domain and a core catalytic domain. It functions in a homodimeric form, which is stabilized by tRNA binding. This gene is regulated by a bidirectional promoter that also controls the expression of mitochondrial ribosomal protein S12. Both genes are within the critical interval for the autosomal dominant deafness locus DFNA4 and might be linked to this disease. Multiple transcript variants encoding different isoforms have been identified for this gene.
Synonyms
SARS2; seryl-tRNA synthetase 2, mitochondrial; SARSM, serine tRNA ligase, mitochondrial , seryl tRNA synthetase 2; seryl-tRNA synthetase, mitochondrial; FLJ20450; mtSerRS; SARS; serine tRNA ligase 2; mitochondrial; SerRSmt; SERS; SYS; SARSM; Serine tRNA ligase; Serine--tRNA ligase; SerRS; Seryl tRNA synthetase 2; Seryl-tRNA synthetase; Seryl-tRNA(Ser/Sec) synthetase; SYSM_HUMAN; serine-tRNA ligase, mitochondrial; mitochondrial seryl-tRNA synthetase; serine tRNA ligase 2, mitochondrial; serine--tRNA ligase, mitochondrial; SerRS2; zgc:66345

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