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RRM1

Official Full Name
ribonucleotide reductase M1
Background
Ribonucleotide reductase M1 polypeptide (RRM1) is one of two non-identical subunits for ribonucleoside-diphosphate reductase, an enzyme which catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RRM1 is present throughout the cell division cycle but downregulated in quiescent cells. RRM1 is involved in carcinogenesis, tumor progression, and the response of non-small-cell lung cancer (NSCLC) to chemotherapy.
Synonyms
RRM1; ribonucleotide reductase M1; ribonucleotide reductase M1 polypeptide; ribonucleoside-diphosphate reductase large subunit; ribonucleotide reductase, R1 subunit; ribonucleotide reductase, large subunit; ribonucleoside-diphosphate reductase subunit M1; R1; RR1; RIR1; R1, RIR1, RR1, RRM1; cb396; cb838; sb:cb548; CHUNP6866; wu:fb39b07; wu:fi14b02; wu:fk95f07; ribonucleotide reductase large subunit; ribonucleotide reductase protein r1 class

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