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RPS6KB1

Official Full Name
ribosomal protein S6 kinase, 70kDa, polypeptide 1
Background
p70S6K is responsible for the phosphorylation of 40Sribosomal protein S6, and is ubiquitously expressed inhuman adult tissues (1). p70S6K is activated by serumstimulation and this activation is inhibited by wortmanninand rapamycin. p70S6k activity changes during the cellcycle, and increases 20-fold in G1 cells released from G0(2). p70S6K activation requires sequential phosphorylationat proline-directed residues in the putative autoinhibitorypseudosubstrate domain, as well as threonine 389, a sitephosphorylated by phosphoinositide-dependent kinase 1(PDK-1).
Synonyms
RPS6KB1; ribosomal protein S6 kinase, 70kDa, polypeptide 1; ribosomal protein S6 kinase, 70kD, polypeptide 1 , STK14A; ribosomal protein S6 kinase beta-1; p70(S6K) alpha; PS6K; S6K1; P70S6K1; p70 S6KA; S6K-beta-1; p70 S6K-alpha; p70 S6 kinase, alpha 1; p70 S6 kinase, alpha 2; ribosomal protein S6 kinase I; serine/threonine kinase 14 alpha; serine/threonine-protein kinase 14A; 70 kDa ribosomal protein S6 kinase 1; S6K; STK14A; p70-S6K; p70-alpha; p70(S6K)-alpha

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