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rnf20

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Official Full Name
ring finger protein 20, E3 ubiquitin protein ligase
Background
The protein encoded by this gene shares similarity with BRE1 of S. cerevisiae. The protein encoded by this human gene is an E3 ubiquitin ligase that regulates chromosome structure by monoubiquitinating histone H2B. This protein acts as a putative tumor suppressor and positively regulates the p53 tumor suppressor as well as numerous histone H2A and H2B genes. In contrast, this protein also suppresses the expression of several protooncogenes and growth-related genes, including many genes that are induced by epidermal growth factor. This gene selectively suppresses the expression of some genes by interfering with chromatin recruitment of transcription elongation factor SII (TFIIS). [provided by RefSeq, Feb 2012]
Synonyms
RNF20; ring finger protein 20, E3 ubiquitin protein ligase; BRE1; BRE1A; hBRE1; E3 ubiquitin-protein ligase BRE1A; BRE1-A; homolog of S. cerevisiae BRE1; BRE1 E3 ubiquitin ligase homolog; ring finger protein 20; BRE1 E3 ubiquitin ligase homolog (S. cerevisiae); FLJ11189; FLJ20382; KAIA2779; KIAA2779; MGC129667; MGC129668; BRE1, BRE1A, hBRE1