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rnf19a

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Official Full Name
ring finger protein 19A, RBR E3 ubiquitin protein ligase
Background
The protein encoded this gene contains two RING-finger motifs and an IBR (in between RING fingers) motif. This protein is an E3 ubiquintin ligase that is localized in Lewy bodies (LBs), a characteristic neuronal inclusion in Parkinsons disease (PD) brains. This protein interacts with UBE2L3/UBCH7 and UBE2E2/UBCH8, but not other ubiquitin-conjugating enzymes. This protein is found to bind and ubiquitylate synphilin 1 (SNCAIP), which is a interacting protein of alpha synuclein in neurons, and a major component of LB. Alternatively spliced transcript variants encoding the same protein have been reported.
Synonyms
RNF19A; ring finger protein 19A; ring finger protein 19 , RNF19; E3 ubiquitin-protein ligase RNF19A; DKFZp566B1346; dorfin; AA032313; Double ring finger protein; Double ring-finger protein; p38; p38 protein; Ring finger protein 19; Ring IBR ring domain containing protein Dorfin; RN19A_HUMAN; RNF19; Ubce7ip2; UIP117; XYbp; OTTHUMP00000227271; OTTHUMP00000227364; RING finger protein 19 isoform; ring-IBR-ring domain containing protein Dorfin; protein p38 interacting with transcription factor Sp1