The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Six alternatively spliced transcript variants encoding two distinct isoforms have been reported.
RNF14; ring finger protein 14; E3 ubiquitin-protein ligase RNF14; ARA54; HFB30; TRIAD2; Androgen receptor associated protein 54; Androgen receptor-associated protein 54; ARA 54; E3 ubiquitin protein ligase RNF14; FLJ26004; HFB 30; HRIHFB2038; RNF 14; RNF14_HUMAN; TRIAD 2; Triad2 protein; OTTHUMP00000160065; OTTHUMP00000160066; zgc:86928; wu:fb80d11; wu:fi42d09