Official Full Name
ring finger protein, LIM domain interacting
The protein encoded by this gene is a RING-H2 zinc finger protein. It has been shown to be an E3 ubiquitin protein ligase that targets LIM domain binding 1 (LDB1/CLIM), and causes proteasome-dependent degradation of LDB1. This protein and LDB1 are co-repressors of LHX1/LIM-1, a homeodomain transcription factor. Multiple alternatively spliced variants, encoding the same protein, have been identified.
RNF12; FLJ25923; FLJ41093; FLJ42887; FLJ45986; MGC15161; NY-REN-43; DKFZp686N06224; E3 ubiquitin-protein ligase RLIM; R-LIM; OTTHUMP00000023574; OTTHUMP00000023575; ring finger protein 12; E3 ubiquitin-protein ligase RNF12; renal carcinoma antigen NY-REN-43; RING finger LIM domain-binding protein; ring zinc finger protein NY-REN-43antigen; LIM domain-interacting RING finger protein; ring zinc finger LIM domain binding protein; RLIM; ring finger protein LIM domain interacting; ring finger protein, LIM domain interacting; LIM domain interacting RING finger protein