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ric8a

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Official Full Name
RIC8 guanine nucleotide exchange factor A
Background
Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.
Synonyms
RIC8A; resistance to inhibitors of cholinesterase 8 homolog A (C. elegans); synembryn-A; synembryn; MGC104517; MGC131931; MGC148073; MGC148074; Protein Ric-8A; RIC8; RIC8A_HUMAN; RIC8 guanine nucleotide exchange factor A; synembryn A; resistance to inhibitors of cholinesterase 8 homolog A; zgc:92294