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rgs18

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Official Full Name
regulator of G-protein signaling 18
Background
This gene encodes a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
Synonyms
RGS18; regulator of G-protein signaling 18; regulator of G protein signalling 18; RGS13; Regulator of G protein signalling 13; RGS 18; RGS18_HUMAN; regulator of G-protein signalling 13; regulator of G-protein signalling 18; zgc:153888