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rfc5

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Official Full Name
replication factor C (activator 1) 5, 36.5kDa
Background
The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 36 kD subunit. This subunit can interact with the C-terminal region of PCNA. It forms a core complex with the 38 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 9.
Synonyms
RFC5; replication factor C (activator 1) 5, 36.5kDa; replication factor C (activator 1) 5 (36.5kD); replication factor C subunit 5; RFC36; 36 kDa subunit; A1 36; A1 36 kDa subunit; A136; Activator 1 36 kDa subunit; Activator 1; Activator 1 subunit 5; Activator 136 kDa subunit; MGC1155; Replication factor C 5 isoform 1; Replication Factor C; Replication Factor C36 kDa subunit; Replication factor c5; RFC 36.5 kD subunit; RFC 5; RF-C 36 kDa subunit; RFC, 36.5 kD subunit; replication factor C, 36-kDa subunit; replication factor C (activator 1) 5; zgc:110313; replication factor C subunit RFC5

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