The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 36 kD subunit. This subunit can interact with the C-terminal region of PCNA. It forms a core complex with the 38 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 9.
RFC5; replication factor C (activator 1) 5, 36.5kDa; replication factor C (activator 1) 5 (36.5kD); replication factor C subunit 5; RFC36; 36 kDa subunit; A1 36; A1 36 kDa subunit; A136; Activator 1 36 kDa subunit; Activator 1; Activator 1 subunit 5; Activator 136 kDa subunit; MGC1155; Replication factor C 5 isoform 1; Replication Factor C; Replication Factor C36 kDa subunit; Replication factor c5; RFC 36.5 kD subunit; RFC 5; RF-C 36 kDa subunit; RFC, 36.5 kD subunit; replication factor C, 36-kDa subunit; replication factor C (activator 1) 5; zgc:110313; replication factor C subunit RFC5