This gene encodes a large secreted extracellular matrix protein thought to control cell-cell interactions critical for;cell positioning and neuronal migration during brain development. This protein may be involved in schizophrenia,;autism, bipolar disorder, major depression and in migration defects associated with temporal lobe epilepsy. Mutations;of this gene are associated with autosomal recessive lissencephaly with cerebellar hypoplasia. Two transcript variants;encoding distinct isoforms have been identified for this gene. Other transcript variants have been described but their;full length nature has not been determined.