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rbpj

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Official Full Name
recombination signal binding protein for immunoglobulin kappa J region
Background
The protein encoded by this gene is a transcriptional regulator important in the Notch signaling pathway. The encoded protein acts as a repressor when not bound to Notch proteins and an activator when bound to Notch proteins. It is thought to function by recruiting chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins to Notch signaling pathway genes. Several transcript variants encoding different isoforms have been found for this gene, and several pseudogenes of this gene exist on chromosome 9. [provided by RefSeq, Oct 2013]
Synonyms
RBPJ; recombination signal binding protein for immunoglobulin kappa J region; SUH; csl; AOS3; CBF1; KBF2; RBP-J; RBPJK; IGKJRB; RBPSUH; IGKJRB1; recombining binding protein suppressor of hairless; CBF-1; RBP-JK; RBP-J kappa; H-2K binding factor-2; suppressor of hairless homolog; renal carcinoma antigen NY-REN-30; immunoglobulin kappa J region recombination signal binding protein 1; IGKJRB1, RBPSUH, recombining binding protein suppressor of hairless (Drosophila); RBP J; suppressor of hairless homolog (Drosophila); MGC61669

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