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rbbp7

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Official Full Name
retinoblastoma binding protein 7
Background
This protein is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat proteins. It is found among several proteins that binds directly to retinoblastoma protein, which regulates cell proliferation. The encoded protein is found in many histone deacetylase complexes, including mSin3 co-repressor complex. It is also present in protein complexes involved in chromatin assembly. This protein can interact with BRCA1 tumor-suppressor gene and may have a role in the regulation of cell proliferation and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
Synonyms
RBBP7; retinoblastoma binding protein 7; RbAp46; histone-binding protein RBBP7; RBBP-7; retinoblastoma-binding protein 7; retinoblastoma-binding protein p46; retinoblastoma-binding protein RbAp46; histone acetyltransferase type B subunit 2; nucleosome-remodeling factor subunit RBAP46; G1/S transition control protein-binding protein RbAp46; G1/S transition control protein binding protein RbAp46; retinoblastoma binding protein p46; retinoblastoma binding protein RbAp46; MGC138867; MGC138868; Rbap46 polypeptide