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rassf8

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Official Full Name
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
Background
This gene encodes a member of the Ras-assocation domain family (RASSF) of tumor suppressor proteins. This gene is;essential for maintaining adherens junction function in epithelial cells and has a role in epithelial cell migration.;It is a lung tumor suppressor gene candidate. A chromosomal translocation t(12;22)(p11.2;q13.3) leading to the fusion;of this gene and the FBLN1 gene is found in a complex type of synpolydactyly. Multiple alternatively spliced;transcript variants encoding different isoforms have been found for this gene.
Synonyms
RASSF8; Ras association (RalGDS/AF-6) domain family (N-terminal) member 8; C12orf2, chromosome 12 open reading frame 2; ras association domain-containing protein 8; HoJ 1; carcinoma-associated protein HOJ-1; HOJ1; C12orf2; FLJ11542; DKFZp434O0227

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