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rassf5

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Official Full Name
Ras association (RalGDS/AF-6) domain family member 5
Background
This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the GTP-activated forms of Ras, Rap1, and several other Ras-like small GTPases. The protein regulates lymphocyte adhesion and suppresses cell growth in response to activated Rap1 or Ras. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms
RASSF5; Ras association (RalGDS/AF-6) domain family member 5; RAPL; Maxp1; NORE1; NORE1A; NORE1B; RASSF3; MGC10823; MGC17344; Ras association domain-containing protein 5; New ras effector 1; Regulator for cell adhesion and polarization enriched in lymphoid tissues; OTTHUMP00000034534; OTTHUMP00000034535; Rap1-binding protein; Ras association (RalGDS/AF-6) domain family 5; Ras effector-like protein; novel Ras effector 1; tumor suppressor RASSF3; regulator for cell adhesion and polarization enriched in lymphoid tissue; RAPL, Maxp1, NORE1, NORE1A, NORE1B, RASSF3

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