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rasgrp1

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Official Full Name
RAS guanyl releasing protein 1 (calcium and DAG-regulated)
Background
This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008]
Synonyms
RASGRP1; RAS guanyl releasing protein 1 (calcium and DAG-regulated); V; RASGRP; hRasGRP1; CALDAG-GEFI; CALDAG-GEFII; RAS guanyl-releasing protein 1; ras activator RasGRP; RAS guanyl nucleotide-releasing protein 1; calcium and DAG-regulated guanine nucleotide exchange factor II; guanine nucleotide exchange factor, calcium- and DAG-regulated, Rap1A; CalDAG GEFII; MGC129998; MGC129999