This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the translocation of this protein to the plasma membrane, where it activates Ras GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene.
RASA4; RAS p21 protein activator 4; ras GTPase-activating protein 4; CAPRI; GAPL; KIAA0538; Ca2+ promoted Ras inactivator; Calcium promoted Ras inactivator; GTPase activating protein like; MGC131890; Ras GTPase activating protein 4; Ca2+-promoted Ras inactivator; calcium-promoted Ras inactivator; rasGAP-activating-like protein 2; FLJ59070; si:dkey-93f15.3