Official Full Name
RAS p21 protein activator 3
The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This family member is an inositol 1,3,4,5-tetrakisphosphate-binding protein, like the closely related RAS p21 protein activator 2. The two family members have distinct pleckstrin-homology domains, with this particular member having a domain consistent with its localization to the plasma membrane.
RASA3; RAS p21 protein activator 3; ras GTPase-activating protein 3; GAP1IP4BP; GAPIII; GAP III; GAP1(IP4BP); GTPase activating protein III; Inositol 1 3 4 5 tetrakisphosphate binding protein; Inositol 1345 tetrakisphosphate binding protein; Ins P4 binding protein; Ins(1 3 4 5)P4 binding protein; Ins(1345)P4 binding protein; MGC46517; MGC47588; Ras GTPase activating protein 3; RASA 3; OTTHUMP00000018781; ins P4-binding protein; Ins(1,3,4,5)P4-binding protein; inositol 1,3,4,5-tetrakisphosphate-binding protein