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rapgef2

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Official Full Name
Rap guanine nucleotide exchange factor (GEF) 2
Background
Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated;switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs),;such as RAPGEF2, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and;are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 (PubMed 10934204)).
Synonyms
RAPGEF2; Rap guanine nucleotide exchange factor (GEF) 2; PDZ domain containing guanine nucleotide exchange factor (GEF) 1 , PDZGEF1; rap guanine nucleotide exchange factor 2; DKFZP586O1422; KIAA0313; PDZ GEF1; RA GEF; Rap GEP; Neural RAP guanine nucleotide exchange protein; nRap GEP; NRAPGEP; PDZ domain containing guanine nucleotide exchange factor 1; PDZ domain-containing guanine nucleotide exchange factor 1; PDZ-GEF1; PDZGEF1; RA-GEF; RPGF2_HUMAN; OTTHUMP00000220255; RA(Ras/Rap1A-associating)-GEF; PDZ domain containing guanine nucleotide exchange factor (G; Rap-GEP; CNrasGEF; PDZ domain containing guanine nucleotide exchange factor (GEF) 1