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rap1a

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Official Full Name
RAP1A, member of RAS oncogene family
Background
The product of this gene belongs to the family of RAS-related proteins. These proteins share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between RAP proteins and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. The product of this gene counteracts the mitogenic function of RAS because it can interact with RAS GAPs and RAF in a competitive manner. Two transcript variants encoding the same protein have been identified for this gene.
Synonyms
RAP1A; RAP1A, member of RAS oncogene family; ras-related protein Rap-1A; KREV 1; SMGP21; C21KG; G 22K; G-22K; GTP binding protein smg p21A; GTP-binding protein smg p21A; KREV1; OTTHUMP00000013741; RAP 1A; RAP1; RAP1A member of RAS oncogene family; RAP1A_HUMAN; Ras related protein Krev 1; Ras related protein Rap 1A; RAS related protein RAP1A; Ras-related protein Krev-1; OTTHUMP00000013740; RAS-related protein RAP1A; KREV-1