This gene belong to the RAET1 family, which consists of major histocompatibility complex (MHC) class I-related genes located in a cluster on chromosome 6q24.2-q25.3. This and RAET1G protein differ from other RAET1 proteins in that they have type I membrane-spanning sequences at their C termini rather than glycosylphosphatidylinositol anchor sequences. This protein functions as a ligand for NKG2D receptor, which is expressed on the surface of several types of immune cells, and is involved in innate and adaptive immune responses. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
RAET1E; retinoic acid early transcript 1E; NKG2D ligand 4; bA350J20.7; LETAL; ULBP4; Lymphocyte effector toxicity activation ligand; MGC125308; MGC125309; N2DL-4; N2DL4; NKG2D ligand 4 precursor; NKG2DL4; RAE-1-like transcript 4; RAET1E2; RL-4; OTTHUMP00000017403; OTTHUMP00000017404; OTTHUMP00000229731