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rad51c

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Official Full Name
RAD51 paralog C
Background
This gene is a member of the RAD51 family of related genes, which encode strand-transfer proteins thought to be;involved in recombinational repair of damaged DNA and in meiotic recombination. This gene product interacts with two;other DNA repair proteins, encoded by RAD51B and XRCC3, but not with itself. The protein copurifies with XRCC3 protein;in a complex, reflecting their endogenous association and suggesting a cooperative role during recombinational repair.;This gene is one of four localized to a region of chromosome 17q23 where amplification occurs frequently in breast;tumors. Overexpression of the four genes during amplification has been observed and suggests a possible role in tumor;progression. Alternative splicing has been observed for this gene and two variants encoding different isoforms have;been identified.
Synonyms
RAD51C; RAD51 homolog C (S. cerevisiae); RAD51 (S. cerevisiae) homolog C; DNA repair protein RAD51 homolog 3; RAD51L2; R51H3; RAD51-like protein 2; yeast RAD51 homolog 3; RAD51 homolog C, isoform 1; FANCO; BROVCA3; MGC104277; RAD51 paralog C; zgc:101596; rad51 homolog C

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