The Rho family of GTPases or small G-proteins, most Rho, and Cdc42, are all implicated in different aspects of regulation of cytoskeletal signaling when in their GTP-bound active state. Rac, Rho and Cdc42 encompass the assembly of actin-based structures such as lamellipodia, stress fibers, and filopodia, respectively. Together they help control the organization of the actin cytoskeleton, proliferation, apoptosis, membrane transport and gene expression. Rac, Cdc42, and Rho work in concert with one a involved in lamellipodia formation,Works with Cdc42,Involved in cell polarization and filopodia formation, through their downstream targets WAVE and WASP, respectively, that signal through the Arp2/3 complex to the actin cytoskeleton. This signaling enables the coordination of cell migration at the leading edge by inducing the migrating cell to stimulate actin-mediated membrane protrusion. The downstream target of Rac,WAVE-1, functions as a scaffolding protein that directs actin reorganization by relaying signals from Rac to the Arp2/3 complex. The continued addition of actin monomers in this branched network is thought to provide the driving force for the extension of the membrane that occurs during lamellipodial protrusion.
RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2); ras-related C3 botulinum toxin substrate 2; EN 7; p21-Rac2; small G protein; rho family, small GTP binding protein Rac2; Ras-related C3 botulinum toxin substrate 3 (rho family, small GTP-binding protein Rac2); Gx; EN-7; HSPC022; zgc:86686