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qprt

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Official Full Name
quinolinate phosphoribosyltransferase
Background
This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimers disease, and Huntingtons disease.
Synonyms
QPRT; quinolinate phosphoribosyltransferase; nicotinate-nucleotide pyrophosphorylase [carboxylating]; nicotinate nucleotide pyrophosphorylase (carboxylating); QPRTase; QAPRTase; nicotinate-nucleotide pyrophosphorylase (carboxylating)

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