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pyhin1

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Official Full Name
Homo sapiens pyrin and HIN domain family, member 1 DNA.
Background
The protein encoded by this gene belongs to the HIN-200 family of interferon-inducible proteins that share a 200-amino acid signature motif at their C-termini. HIN200 proteins are primarily nuclear and are involved in transcriptional regulation of genes important for cell cycle control, differentiation, and apoptosis. Downregulation of this gene is associated with breast cancer. This protein acts as a tumor suppressor by promoting ubiquitination and subsequent degradation of MDM2, which leads to stabilization of p53/TP53. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Synonyms
PYHIN1; pyrin and HIN domain family, member 1; pyrin and HIN domain-containing protein 1; IFIX; MGC23885; IFIX_HUMAN; Interferon-inducible protein X; OTTHUMP00000035198; OTTHUMP00000035199; OTTHUMP00000035200; OTTHUMP00000035201; RP11-520H16.1; IFIX, RP11-520H16.1