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pvrl4

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Official Full Name
poliovirus receptor-related 4
Background
This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.
Synonyms
PVRL4; poliovirus receptor-related 4; poliovirus receptor-related protein 4; LNIR; nectin 4; PRR4; Ig superfamily receptor LNIR; Nectin-4; Processed poliovirus receptor-related protein 4; PVRL4_HUMAN; OTTHUMP00000029698; EDSS1; DKFZp686K05193

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