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pvrl2

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Official Full Name
Mus musculus poliovirus receptor-related 2 DNA.
Background
This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Synonyms
PVRL2; poliovirus receptor-related 2 (herpesvirus entry mediator B); HVEB; PRR2; CD112; PVRR2; poliovirus receptor-related protein 2; nectin-2; poliovirus receptor-like 2; herpesvirus entry protein B; MPH; Pvr; Pvs; AI325026; AI987993

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