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puf60

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Official Full Name
poly-U binding splicing factor 60KDa
Background
The protein encoded by this gene is a Ro RNP-binding protein. It interacts with Ro RNPs and their interaction is thought to represent a gain of function for Ro RNPs. This protein also forms a ternary complex with far upstream element (FUSE) and FUSE-binding protein. It can repress a c-myc reporter via the FUSE. It is also known to target transcription factor IIH and inhibit activated transcription. This gene is implicated in the xeroderma pigmentosum disorder. There are two alternatively spliced transcript variants of this gene encoding different isoforms. There seems to be evidence of multiple polyadenylation sites for this gene.
Synonyms
PUF60; poly-U binding splicing factor 60KDa; poly(U)-binding-splicing factor PUF60; FBP interacting repressor; FIR; pyrimidine tract binding splicing factor; Ro ribonucleoprotein binding protein 1; RoBPI; siah binding protein 1; SIAHBP1; FLJ31379; fuse-binding protein-interacting repressor; poly-U binding splicing factor PUF60; Ro ribonucleoprotein-binding protein 1; roBP1; siah-BP1; ro-binding protein 1; siah-binding protein 1; FBP-interacting repressor; 60 kDa poly(U)-binding-splicing factor; VRJS