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ptpro

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Official Full Name
protein tyrosine phosphatase, receptor type, O
Background
This gene encodes a member of the R3 subtype family of receptor-type protein tyrosine phosphatases. These proteins are localized to the apical surface of polarized cells and may have tissue-specific functions through activation of Src family kinases. This gene contains two distinct promoters, and alternatively spliced transcript variants encoding multiple isoforms have been observed. The encoded proteins may have multiple isoform-specific and tissue-specific functions, including the regulation of osteoclast production and activity, inhibition of cell proliferation and facilitation of apoptosis. This gene is a candidate tumor suppressor, and decreased expression of this gene has been observed in several types of cancer.
Synonyms
PTPRO; protein tyrosine phosphatase, receptor type, O; receptor-type tyrosine-protein phosphatase O; GLEPP1; NPHS6; osteoclastic transmembrane protein tyrosine phosphatase; PTP oc; PTP U2; PTPU2; GLEPP 1; Glomerular epithelial protein 1; Phosphotyrosine phosphatase U2; Protein tyrosine phosphatase PTP U2; Protein tyrosine phosphatase PTPU2; Protein tyrosine phosphatase receptor type O; Protein tyrosine phosphatase U2; PTP-U2; PTPase U2; PTPRO_HUMAN; PTPROt; PTPU 2; R-PTP-O; Receptor type protein tyrosine phosphatase O; Receptor type tyrosine protein phosphatase O; PTP phi; protein tyrosine phosphatase PTP-U2; osteoclastic transmembrane protein-tyrosine phosphatase; PTP-OC; zgc:158179; PTP