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ptprg

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Official Full Name
protein tyrosine phosphatase, receptor type, G
Background
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this PTP contains a carbonic anhydrase-like (CAH) domain, which is also found in the extracellular region of PTPRBETA/ZETA. This gene is located in a chromosomal region that is frequently deleted in renal cell carcinoma and lung carcinoma, thus is thought to be a candidate tumor suppressor gene.
Synonyms
PTPRG; protein tyrosine phosphatase, receptor type, G; PTPG; receptor-type tyrosine-protein phosphatase gamma; RPTPG; H RG317H01.1; HPTPG; Protein tyrosine phosphatase gamma; Protein tyrosine phosphatase receptor type G; Protein tyrosine phosphatase receptor type gamma polypeptide; Protein-tyrosine phosphatase gamma; PTPgamma; PTPRG protein; PTPRG_HUMAN; R PTP Gamma; R-PTP-gamma; Receptor type protein phosphatase gamma; Receptor type tyrosine protein phosphatase gamma; Receptor tyrosine phosphatase gamma; H_RG317H01.1; OTTHUMP00000213232; OTTHUMP00000213233; receptor-type protein phosphatase gamma; receptor type protein tyrosine phosphatase gamma; protein tyrosine phosphatase, receptor type, gamma polypeptide