The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.
PTPN3; protein tyrosine phosphatase, non-receptor type 3; tyrosine-protein phosphatase non-receptor type 3; PTPH1; protein-tyrosine phosphatase H1; cytoskeletal-associated protein tyrosine phosphatase; PTP-H1; DKFZp686N0569; PTPH1, PTP-H1