The protein encoded by this gene belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are;cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a;protein tyrosine phosphatase catalytic domain and a characteristic C-terminal prenylation motif. This PTP has been;shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP was;found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a;regulator of GGT II activity. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which;suggested its role in tumorigenesis. Alternatively spliced transcript variants have been described. Related;pseudogenes exist on chromosomes 11, 12 and 17.
PTP4A2; protein tyrosine phosphatase type IVA, member 2; PTP4A; protein tyrosine phosphatase type IVA 2; HU PP 1; OV 1; PRL 2; ptp IV1a; PTPCAAX2; PTP(CAAXII); protein tyrosine phosphatase IVA; protein-tyrosine phosphatase 4a2; protein tyrosine phosphatase IVA2; phosphatase of regenerating liver 2; protein-tyrosine phosphatase of regenerating liver 2; HH13; OV-1; PRL2; HH7-2; PRL-2; HU-PP-1; ptp-IV1a; ptp-IV1b; HH13, OV-1, PRL2, HH7-2, PRL-2, PTP4A, HU-PP-1, PTPCAAX2, ptp-IV1a, ptp-IV1b