Prostaglandin D synthase (PGDS) catalyzes the isomerization of PGH2 to produce PGD2. Lipocalin-type PGDS (L-PGDS, a.k.a.β-trace) is a homodimer with each subunit ranging in size from 20-31 kDa, depending on glycosylation. L-PGDS has two functions: it catalyzes the conversion of PGH2 to PGD2 and acts as a carrier protein for lipid-like molecules (i.e., retinoids and thyroid hormones). PGD2 is involved in sleep regulation, nociception, platelet aggregation, and allergic and inflammatory responses. There is also some evidence to indicate the involvement of PGD2 and its J-series metabolites in pregnancy and parturition.
PTGDS; prostaglandin D2 synthase 21kDa (brain); prostaglandin D2 synthase (21kD, brain); prostaglandin-H2 D-isomerase; L PGDS; lipocalin type prostaglandin D synthase; PGDS; cerebrin-28; PGD2 synthase; beta-trace protein; prostaglandin D synthase; prostaglandin-D2 synthase; glutathione-independent PGD synthase; glutathione-independent PGD synthetase; lipocalin-type prostaglandin D synthase; lipocalin-type prostaglandin-D synthase; PDS; PGD2; LPGDS; PGDS2; L-PGDS