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ptf1a

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Official Full Name
pancreas specific transcription factor, 1a
Background
This gene encodes a protein that is a component of the pancreas transcription factor 1 complex (PTF1) and is known to have a role in mammalian pancreatic development. The protein plays a role in determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. The protein is thought to be involved in the maintenance of exocrine pancreas-specific gene expression including elastase 1 and amylase. Mutations in this gene cause cerebellar agenesis and loss of expression is seen in ductal type pancreas cancers.
Synonyms
PTF1A; pancreas specific transcription factor, 1a; pancreas transcription factor 1 subunit alpha; bHLHa29; PTF1 p48; class II bHLH protein PTF1A; bHLH transcription factor p48; class A basic helix-loop-helix protein 29; pancreas-specific transcription fac; PTF1; zgc:112216; si:zc142h2.2; Ptfa; pancreas-specific transcription factor 1a

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