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ptch2

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Official Full Name
patched 2
Background
This gene encodes a transmembrane receptor of the patched gene family. The encoded protein may function as a tumor suppressor in the hedgehog signaling pathway. Alterations in this gene have been associated with nevoid basal cell carcinoma syndrome, basal cell carcinoma, medulloblastoma, and susceptibility to congenital macrostomia. Alternatively spliced transcript variants have been described.
Synonyms
PTC2; PTCH2; Patched Tumor Suppressor 2; protein patched homolog 2; patched homolog 2; OTTHUMP00000010158; patched 2; ptc1; ptc-1; ptch1; protein patched homolog 1; blw; blowout; patched 1; etID309849.2

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