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pstpip1

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Official Full Name
proline-serine-threonine phosphatase interacting protein 1
Background
The protein encoded by this gene binds to the cytoplasmic tail of CD2, an effector of T cell activation and adhesion, negatively affecting CD2-triggered T cell activation. The encoded protein appears to be a scaffold protein and a regulator of the actin cytoskeleton. It has also been shown to bind ABL1, PTPN18, WAS, CD2AP, and PTPN12. Mutations in this gene are a cause of PAPA syndrome.
Synonyms
PSTPIP1; proline-serine-threonine phosphatase interacting protein 1; proline-serine-threonine phosphatase-interacting protein 1; CD2 antigen binding protein 1; CD2 cytoplasmic tail binding protein; CD2BP1; CD2BP1L; CD2BP1S; H PIP; PAPAS; PEST phosphatase interacting protein 1; PSTPIP; CD2 binding protein 1; HPIP; Proline serine threonine phosphatase interacting protein 1; CD2-binding protein 1; CD2 antigen-binding protein 1; CD2 cytoplasmic tail-binding protein; PEST phosphatase-interacting protein 1; H-PIP