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psmd5

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Official Full Name
proteasome (prosome, macropain) 26S subunit, non-ATPase, 5
Background
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway.An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator base.
Synonyms
PSMD5; proteasome (prosome, macropain) 26S subunit, non-ATPase, 5; 26S proteasome non-ATPase regulatory subunit 5; KIAA0072; S5B; 26S proteasome subunit S5B; 26S protease subunit S5 basic; MGC23145; im:7137623; zgc:110116; proteasome 26S non-ATPase subunit 5