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psmd3

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Official Full Name
proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
Background
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid.
Synonyms
PSMD3; proteasome (prosome, macropain) 26S subunit, non-ATPase, 3; tissue specific transplantation antigen 2 , TSTA2; 26S proteasome non-ATPase regulatory subunit 3; P58; Rpn3; S3; 26S proteasome non ATPase regulatory subunit 3; 26S proteasome regulatory subunit RPN3; 26S proteasome regulatory subunit S3; OTTHUMP00000164347; Proteasome (prosome, macropain) 26S subunit non ATPase 3; Proteasome subunit p58; PSMD3_HUMAN; Tissue specific transplantation antigen 2; TSTA2; zgc:65867; zgc:77369