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psmd2

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Official Full Name
proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
Background
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway.An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. In addition to participation in proteasome function, this subunit may also participate in the TNF signalling pathway since it interacts with the tumor necrosis factor type 1 receptor. A pseudogene has been identified on chromosome 1.
Synonyms
PSMD2; proteasome (prosome, macropain) 26S subunit, non-ATPase, 2; 26S proteasome non-ATPase regulatory subunit 2; MGC14274; P97; Rpn1; S2; TRAP2; 26S proteasome non ATPase regulatory subunit 2; 26S proteasome regulatory subunit RPN1; 26S proteasome regulatory subunit S2; 26S proteasome subunit p97; 55.11 protein; Proteasome (prosome macropain) 26S subunit non ATPase 2; Proteasome 26S subunit non ATPase 2; Protein 55.11; PSMD 2; PSMD2_HUMAN; TNFR associated protein 2; TRAP 2; Tumor necrosis factor receptor associated protein 2; Tumor necrosis factor type 1 receptor associated protein 2; Tumor necrosis factor type 1 receptor-associated protein 2; OTTHUMP00000210627; OTTHUMP00000210628; OTTHUMP00000210629; TNFR-associated protein 2; tumor necrosis factor receptor-associated protein 2; proteasome 26S non-ATPase subunit 2; zgc:65921

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